Meiyu Geng Selected Research

Neoplasms (Cancer)

4/2024	Identification of benzo[b]thiophene-1,1-dioxide derivatives as novel PHGDH covalent inhibitors.
3/2024	Oncogenic KRAS induces arginine auxotrophy and confers a therapeutic vulnerability to SLC7A1 inhibition in non-small cell lung cancer.
2/2024	A novel strategy for treating oncogene-mutated tumors by targeting tumor microenvironment and synergistically enhancing anti-PD-1 immunotherapy.
1/2024	Discovery of hematopoietic progenitor kinase 1 inhibitors using machine learning-based screening and free energy perturbation.
1/2024	Low-Dose Chemotherapy Preferentially Shapes the Ileal Microbiome and Augments the Response to Immune Checkpoint Blockade by Activating AIM2 Inflammasome in Ileal Epithelial Cells.
12/2023	Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma.
11/2023	Unprecedented sesterterpenoids, orientanoids A-C: discovery, bioinspired total synthesis and antitumor immunity.
11/2023	Tetrandrine synergizes with MAPK inhibitors in treating KRAS-mutant pancreatic ductal adenocarcinoma via collaboratively modulating the TRAIL-death receptor axis.
6/2023	Photochemically controlled activation of STING by CAIX-targeting photocaged agonists to suppress tumor cell growth.
1/2023	Structural Modification and Pharmacological Evaluation of Substituted Quinoline-5,8-diones as Potent NSD2 Inhibitors.

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Meiyu Geng Research Topics

Disease

100	Neoplasms (Cancer) 04/2024 - 09/2006
12	Neoplasm Metastasis (Metastasis) 04/2024 - 09/2006
10	Breast Neoplasms (Breast Cancer) 01/2022 - 01/2011
8	Bites and Stings (Sting) 04/2024 - 11/2021
6	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 03/2024 - 01/2017
6	Alzheimer Disease (Alzheimer's Disease) 04/2023 - 01/2007
5	Acquired Immunodeficiency Syndrome (AIDS) 01/2008 - 08/2004
4	Hepatocellular Carcinoma (Hepatoma) 01/2019 - 11/2011
3	Melanoma (Melanoma, Malignant) 01/2024 - 06/2017
3	Lung Neoplasms (Lung Cancer) 09/2022 - 02/2015
3	Squamous Cell Carcinoma of Head and Neck 01/2020 - 01/2015
3	Hematologic Neoplasms (Hematological Malignancy) 01/2019 - 12/2016
3	Inflammation (Inflammations) 01/2018 - 11/2011
2	Autoimmune Diseases (Autoimmune Disease) 04/2024 - 06/2017
2	Carcinogenesis 04/2024 - 01/2016
2	Adenocarcinoma 11/2023 - 01/2011
2	Dementia (Dementias) 01/2021 - 01/2020
2	Neuroinflammatory Diseases 10/2019 - 04/2006
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2019 - 01/2018
1	Enteritis 01/2022

Drug/Important Bio-Agent (IBA)

21	Phosphotransferases (Kinase)IBA 01/2020 - 01/2012
11	Proteins (Proteins, Gene)FDA Link 06/2023 - 05/2005
9	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA 01/2023 - 07/2015
8	InterferonsIBA 04/2024 - 11/2021
7	EnzymesIBA 04/2024 - 08/2015
5	CytokinesIBA 04/2024 - 01/2005
5	SodiumIBA 04/2023 - 10/2019
5	Phosphoglycerate Mutase (Phosphoglyceromutase)IBA 01/2020 - 01/2017
5	OligosaccharidesIBA 06/2014 - 02/2005
4	Serine (L-Serine)FDA Link 04/2024 - 01/2017
4	Biomarkers (Surrogate Marker)IBA 01/2023 - 11/2011
4	Histone Deacetylase InhibitorsIBA 01/2022 - 01/2016
4	Histone Deacetylases (Histone Deacetylase)IBA 01/2019 - 03/2011
4	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 07/2018 - 01/2012
4	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 02/2017 - 01/2008
4	oligomannurarate sulfateIBA 06/2014 - 09/2006
4	sulfated polymannuroguluronateIBA 04/2006 - 08/2004
3	DNA (Deoxyribonucleic Acid)IBA 04/2024 - 02/2015
3	Reactive Oxygen Species (Oxygen Radicals)IBA 09/2022 - 04/2006
3	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2018 - 01/2012
3	heparanaseIBA 10/2017 - 09/2006
3	Tyrosine (L-Tyrosine)FDA Link 01/2017 - 01/2016
3	Polysaccharides (Glycans)IBA 07/2010 - 08/2004
3	Anti-HIV Agents (AIDS Drugs)IBA 07/2005 - 08/2004
2	pyrimidineIBA 03/2024 - 01/2022
2	Arginine (L-Arginine)FDA Link 03/2024 - 11/2021
2	InflammasomesIBA 01/2024 - 06/2017
2	NF-kappa B (NF-kB)IBA 06/2023 - 01/2012
2	Tyrosine Kinase InhibitorsIBA 01/2023 - 01/2008
2	ErbB Receptors (EGF Receptor)IBA 01/2023 - 02/2022
2	osimertinibIBA 01/2023 - 02/2022
2	Histone-Lysine N-MethyltransferaseIBA 01/2023 - 01/2022
2	AcidsIBA 11/2022 - 01/2022
2	Lysine (L-Lysine)FDA Link 09/2022 - 08/2015
2	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 09/2022 - 10/2021
2	Histones (Histone)IBA 09/2022 - 01/2018
2	Adenosine Triphosphate (ATP)IBA 09/2022 - 01/2011
2	Lactic Acid (Lactate)FDA LinkGeneric 09/2022 - 01/2019
2	Protein Isoforms (Isoforms)IBA 08/2022 - 11/2021
2	Therapeutic UsesIBA 01/2022 - 08/2021
2	coactivator-associated arginine methyltransferase 1IBA 11/2021 - 01/2019
2	Histone MethyltransferasesIBA 10/2021 - 02/2015
2	undecylprodigiosinIBA 01/2020 - 01/2013
2	Amino Acids FDA Link 10/2019 - 04/2006
2	Antineoplastic Agents (Antineoplastics)IBA 03/2018 - 08/2015
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2018 - 01/2012
2	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 10/2017 - 10/2017
2	CeramidesIBA 06/2017 - 10/2015
2	Glucose (Dextrose)FDA LinkGeneric 01/2017 - 11/2015
2	Polymeric Immunoglobulin Receptors (Polymeric Immunoglobulin Receptor)IBA 01/2017 - 11/2011
2	Pyruvate Dehydrogenase Acetyl-Transferring KinaseIBA 11/2015 - 12/2014
2	Actin Depolymerizing Factors (Cofilins)IBA 06/2014 - 12/2013
2	Tamoxifen FDA LinkGeneric 01/2013 - 01/2013
2	tat Gene Products (tat Protein)IBA 01/2008 - 04/2006
1	Phosphoglycerate Dehydrogenase (Dehydrogenase, Phosphoglycerate)IBA 04/2024
1	Urea (Carbamide)FDA LinkGeneric 03/2024
1	CitrullineIBA 03/2024
1	Aspartic Acid (Aspartate)FDA Link 03/2024
1	Argininosuccinate Synthase (Argininosuccinate Synthetase)IBA 03/2024
1	hematopoietic progenitor kinase 1IBA 01/2024
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2024
1	Temozolomide (Temodar)FDA LinkGeneric 12/2023
1	tetrandrineIBA 11/2023
1	Death Domain ReceptorsIBA 11/2023
1	Carbonic Anhydrase InhibitorsIBA 06/2023
1	Messenger RNA (mRNA)IBA 06/2023
1	cyclic diadenosine phosphateIBA 01/2023
1	Adenosine Monophosphate (AMP)IBA 01/2023
1	LigandsIBA 12/2022
1	ADU-S100IBA 11/2022
1	benzothiopheneIBA 11/2022
1	Lactate Dehydrogenase 5IBA 09/2022
1	imidazoleIBA 08/2022
1	LS-106IBA 02/2022
1	Dextran SulfateIBA 01/2022
1	quinolineIBA 01/2022

Therapy/Procedure

45	Therapeutics 11/2023 - 01/2005
8	Immunotherapy 02/2024 - 11/2021
7	Oral Administration 01/2023 - 01/2016
4	Drug Therapy (Chemotherapy) 01/2024 - 01/2012